Chief Scientist: LI Jianke
Brief introduction of Chief Scientist:
As a Ph. D supervisor, he received Ph.D in Zhejiang University. Now he is the Chief Scientist of innovation team of honeybee proteomics of Agricultural Science and Technology Innovation Program (CAAS-ASTIP-2015-IAR). Apart from this major grant, he is also involved in the key state project of the earmarked fund for Modern Agro-Industry Technology Research System (CARS-45) inChina.
The major research interests are: revealing the molecular basis of honeybee biology implicated in improving the quality and production of royal jelly, functional investigation into the biological roles and heath promoting activity of royal jelly for both honeybee and human, and unraveling the mechanism of honeybee embryogenesis. The team he led is now becoming the leader in the honeybee proteomics around the globe. > 30 papers of honeybee proteomic research have published in high rank international journal such as Molecular Cellular Proteomics and Journal of proteome research, and the total impact factor is over 150. Being as reviewer, he has reviewed many papers for Journal of Proteome Research, Journal of Proteomics ect. “Revealing the mechanism of the high yield and biochemical characteristics of royal jelly” won the second price of scientific and technological achievements by Beijing committee of science and technology in 2013.
Objectives:
Toward the goal of enhancing overall performance of the beekeeping industry and innovative ability of honeybee science inChina, the objective of our team is to research on the key technologies and theories that are important for honeybees. Our main focus is to reveal the molecular basis of honeybee biology implicated in improving the quality and production of royal jelly, functional investigation into the biological roles and heath promoting activity of royal jelly for both honeybee and human, and unraveling the mechanism of honeybee embryogenesis.
Research Focus:
1) Revealing the molecular mechanism of the honeybee biology such as royal jelly production using proteomics and gene editing approaches.
2) Functional investigation of royal jelly using glycoproteomics and phosphoproteomics
3) Deciphering the honeybee embryogenesis by proteomics and gene editing.
Achievements:
Awards: Revealing the mechanism of the high yield and biochemical characteristics of royal jelly won the second price of scientific and technological achievements by Beijing committee of science and technology in 2013.
Selected Publications:
1. Bin Han, Yu Fang, Mao Feng, Han Hu, Yuping Qi, Xinmei Huo, Lifeng Meng, Bin Wu, Jianke Li. Quantitative neuropeptidome analysis reveals neuropeptides are correlated with social behavior regulation of the honeybee workers. J Proteome Res. 2015 Aug 27. [Epub ahead of print] (IF 4.25)
2. Yu Fang, Mao Feng, Bin Han, Yuping Qi Y, Han Hu, Pei Fan, Xinmei Huo, Lifeng Meng, Jianke Li. Proteome Analysis Unravels Mechanism Underling the Embryogenesis of the Honeybee Drone and Its Divergence with the Worker (Apis mellifera lingustica). J Proteome Res. 2015 Aug 14. [Epub ahead of print] (IF 4.25)
3. Bin Han, Yu Fang, Mao Feng, Xiaoshan Lu, Xinmei Huo, Lifeng Meng, Bin Wu and Jianke Li. In-depth Phosphoproteomic Analysis of Royal Jelly Derived from Western and Eastern Honeybee Species. J Proteome Res. 2014, 13 (12), 5928–5943 (IF 5.1).
4. Yu Fang, Mao Feng, Bin Han, XiaoShan Lu, Haitham Ramadan, Jianke Li. In-depth Proteomics Characterization of Embryogenesis of the Honey Bee Worker (Apis mellifera L.). Mol Cell Proteomics. 2014, 13 (9): 2306-2320. (IF 7.25)
5. Mao Feng, Haitham Ramadan, Bin Han, Yu Fang and Jianke Li. Hemolymph proteome changes during worker brood development match the biological divergences between western honey bees (Apis mellifera) and eastern honey bees (Apis cerana). BMC Genomics, 2014, 2014, 15:563 (IF 4.4).
6. Lan Zhang, Bin Han, Rongli Li, Xiaoshan Lu, Yu Fang, Mao Feng, Jianke Li.. Comprehensive identification of novel proteins and N-glycosylation sites in royal jelly. BMC Genomics, 2014,15:135. (IF 4.4)
7. Aijuan Zheng, Jianjie Luo, Kun Meng, Jianke Li, Shu Zhang, Ke Li, Guohua Liu, Huiyi Cai, Wayne Bryden and Bin Yao. Proteome changes underpin improved meat quality and yield of chickens (Gallus gallus) fed the probiotic Enterococcus faecium. BMC Genomics,2014, 15:1167. (IF 4.4)
8. Rongli Li, Lan Zhang, Yu Fang, Bin Han, Xiaoshan Lu, Tiane Zhou, Mao Feng, Jianke Li. Proteome and phosphoproteome analysis of honeybee (Apis mellifera) venom collected from electrical stimulation and manual extraction of the venom gland. BMC genomics, 2013, 14(1),766. (IF 4.4)
9. Alemayehu Gala, Yu Fang, Dereje Woltedji, Lan Zhang, Bin Han, Mao Feng, Jianke Li. Changes of Proteome and Phosphoproteome Trigger Embryo-larva Transition of Honeybee Worker (Apis mellifera ligustica). J Proteomics. 2013, 78, 428-46. (IF 4.9)
10. Bin Han, Lan Zhang, Mao Feng, Yu Fang, Jianke Li. An Integrated Proteomics Reveals Pathological Mechanism of Honeybee (Apis cerena) Sacbrood Disease. J Proteome Res. 2013, 12, 1881-97. (IF 5.1)
11. Dereje Woltedji, Yu Fang, Bin Han, Mao Feng, Rongli Li, Alemayehu Gala, Jianke Li. Proteome Analysis of Hemolymph Changes during the Larval to Pupal Development Stages of Honeybee Workers (Apis mellifera ligustica). J Proteome Res. 2013, 12(11), 5189-98. (IF 5.1)
12. Mao Feng, Yu Fang, Bin Han, Lan Zhang, Xiaoshan Lu, Jianke Li. Novel aspects of understanding molecular working mechanisms of salivary glands of worker honeybees (Apis mellifera) investigated by proteomics and phosphoproteomics. J Proteomics. 2013; 87, 1-15. (IF 4.1)
13. Li, HL; Zhang, LY  ; Ni, CX  ; Shang, HW  ; Zhuang, SL  ; Li, JK. Molecular recognition of floral volatile with two olfactory related proteins in the Eastern honeybee (Apis cerana). Int J Biol Macromol, 2013, 56: 114-21. (IF 2.6)
14. Desalegn Begna, Bin Han, Mao Feng, Yu Fang, Jianke Li. Differential Expressions of Nuclear Proteomes between Honeybee (Apis mellifera L.) Queen and Worker Larvae: A Deep Insight into Caste Pathway Decisions. J. Proteome Res. 2012, 11 (2), 1317-29. (IF 5.1)
15. Woltedji Dereje, Song Feifei, Zhang Lan, Alemayehu Gala, Han Bin, Feng Mao, Fang Yu, Jianke Li. Western Honeybee Drones and Workers (Apis mellifera ligustica) Have Different Olfactory Mechanisms than Eastern Honeybees (Apis cerana cerana). J Proteome Res. 2012, 11, 4526-40. (IF 5.1)